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101.
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103.
Kyoko Moritani Naoko Nakano Sachiko Yonezawa Fumihiro Ochi Hisamichi Tauchi Minenori Eguchi-Ishimae 《Pediatric hematology and oncology》2018,35(2):125-130
Primary bone marrow lymphoma (PBML) is hard to diagnose in children, due to the difficult identification of malignant cells in bone marrow. The first case, a 5-year-old boy, showed knee swelling with an intermittent fever. The second case, a 12-year-old girl, showed fever of unknown origin without lymphadenopathy or hepatosplenomegaly. In both cases, the diagnosis was not confirmed despite the repeated bone marrow aspirations. Finally, bone marrow aspiration and biopsy at the positive site by positron emission tomography (PET)-CT contributed to definitive diagnosis of PBML. The PET-CT is useful for the accurate diagnosis of PBML in children with non-specific symptoms. 相似文献
104.
Naohito Hato Mika Tsujimura Taro Takagi Masahiro Okada Kiyofumi Gyo Mikiko Tohyama Hisamichi Tauchi 《Auris, nasus, larynx》2013
The first reported case of facial paralysis due to an inflammatory pseudotumor (IPT) of the facial nerve as a complication of epidermal nevus syndrome (ENS) is herein presented. A 10-month-old female patient was diagnosed with ENS at 3 months of age. She was referred to us because of moderate left facial paralysis. Epidermal nevi of her left auricle extended deep into the external ear canal. Otoscopy revealed polypous nevi and cholesteatoma debris filling the left ear. Computed tomography showed a soft mass filling the ear canal, including the middle ear, and an enormously enlarged facial nerve. Surgical exploration revealed numerous polypous nevi, external ear cholesteatoma, and tumorous swelling of the facial nerve. The middle ear ossicles were completely lost. The facial paralysis was improved after decompression surgery, but recurred 5 months later. A second operation was conducted 10 months after the first. During this operation, facial nerve decompression was completed from the geniculate ganglion to near the stylomastoid foramen. Histological diagnosis of the facial nerve tumor was IPT probably caused by chronic external ear inflammation induced by epidermal nevi. The facial paralysis gradually improved to House–Blackmann grade III 5 years after the second operation. 相似文献
105.
Shinichi Watanabe Akihiro Tanaka Tomoko Ono Masaaki Ohta Hitoshi Miyamoto Hisamichi Tauchi Mamoru Tanaka Katsuya Suemaru Hiroaki Araki 《European journal of pediatrics》2013,172(10):1419-1421
Recent findings have focused on the possible role of linezolid (LZD) as a suitable candidate for the treatment of central nervous system infections. LZD treatment for meningitis has been sporadically reported in adults, but there are no reports in neonates or infants. We report a case of meningitis caused by methicillin-resistant Staphylococcus epidermidis (MRSE) in a neonatal girl. The patient had intraventricular hemorrhage on postnatal day 1 and was treated with ventricular drainage. Twenty-two days after drainage, the patient developed a fever and seizure. Although ampicillin and ceftriaxone were given empirically for meningitis, an increased cell count and protein were observed in cerebrospinal fluid (CSF). Vancomycin (VCM) was administered intravenously because MRSE was detected from CSF 2 days after the administration of ampicillin and ceftriaxone. However, intravenous administration of VCM did not show any effect. Subsequent treatment of LZD successfully reduced the cell count and protein in CSF. Conclusion: LZD may be a treatment option for neonates and infants for drain-associated meningitis caused by MRSE. 相似文献
106.
Expression of genes involved in repair of DNA double-strand breaks in normal and tumor tissues 总被引:6,自引:0,他引:6
Sakata K Matsumoto Y Tauchi H Satoh M Oouchi A Nagakura H Koito K Hosoi Y Suzuki N Komatsu K Hareyama M 《International journal of radiation oncology, biology, physics》2001,49(1):161-167
BACKGROUND: DNA double-strand breaks (DSB) are the major lethal lesions induced by ionizing radiation. The capability for DNA DSB repair is crucial for inherent radiosensitivity of tumor and normal cells. DNA-PKcs, Ku 70, Ku 85, Xrcc4, and Nbs1 play a critical role in DNA DSB repair. METHODS: We immunohistochemically investigated the expression of DNA-PKcs, Ku 70, Ku85, Xrcc4, and Nbs1 in 134 specimens from various normal and tumor tissues with different radiosensitivity. RESULTS AND CONCLUSION: Immunopositivity to Ku70, Ku85, DNA-PKcs, Xrcc4, and Nbs1 was found in all tumor tissues examined. The staining for Ku70, Ku85, and DNA-PKcs was nuclear; but, for Xrcc4 and Nbs1, it was nuclear and cytoplasmic. There were no apparent differences in the expression of these five proteins among cancerous tissues and the corresponding normal tissues. No apparent differences in nuclear staining intensity were detected in the expression of these five proteins among tumor tissues with different radiosensitivity, although non-Hodgkins' lymphoma (B or T cell) tended to show a lower expression than the others. The stromal cells generally expressed these five proteins at much lower frequency than either tumor or epithelial cells in both tumor and normal tissues. 相似文献
107.
Koichi Azuma Tetsuro Sasada Akihiko Kawahara Satoshi Hattori Takashi Kinoshita Sinzo Takamori Masao Ichiki Youhei Imamura Jiro Ikeda Masayoshi Kage Michihiko Kuwano Hisamichi Aizawa 《Cancer chemotherapy and pharmacology》2009,64(3):565-573
Introduction The expression of excision repair cross-complementation group 1 (ERCC1) is reported to be correlated with resistance to platinum-based
drugs. Class III β-tubulin is reported to be correlated with resistance to taxanes.
Methods In the present study, we evaluated whether ERCC1 and class III β-tubulin expression could be used to predict progression-free
and/or overall survival in 34 patients with locally advanced non-small cell lung cancer (NSCLC) receiving concurrent chemoradiation
therapy with cisplatin and docetaxel, and immunohistochemistry was used to examine the expression of these two proteins in
tumor samples obtained from the patients.
Results Immunostaining for ERCC1 and class III β-tubulin was positive in 16 and 12 patients, respectively. A significant correlation
was observed between ERCC1 expression and response to chemotherapy (P = 0.012), and between class III β-tubulin expression and histology (P = 0.029). Patients negative for ERCC1 had a significantly longer median progression-free (62.5 vs. 36 weeks, P = 0.009), but not overall (171 vs. 50.5 weeks, P = 0.208), survival than those positive for ERCC1. Expression of class III β-tubulin was not correlated with progression-free
or overall survival (P = 0.563 and P = 0.265, respectively). Multivariate analysis adjusting for possible confounding factors showed that negative ERCC1 expression
(hazard ratio = 3.972, P = 0.009) was a significantly favorable factor for progression-free survival.
Conclusions This retrospective study indicates that immunostaining for ERCC1 may be useful for predicting survival in NSCLC patients receiving
concurrent chemoradiotherapy with cisplatin and docetaxel, and can provide information critical for planning personalized
chemotherapy. 相似文献
108.
Motoharu Narimatsu Hisamichi Baba Koji Hashizume Hiroshi Yamaguchi Katsuo Nishi Tsuneo Ariyoshi 《General thoracic and cardiovascular surgery》1999,47(8):407-410
A 56-year-old man admitted to our hospital for cardiac tamponade due to dilated cardiomyopathy did not respond to treatment by usual medical means or surgery. Pericardio-peritoneal drainage was conducted using a subcostal approach. Seven months later, the patient remains well and free of signs of pericardial tamponade. This method has proved to be safe and effective in patients with persistent massive pericardial effusion. 相似文献
109.